The function and therapeutic targeting of anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC)

Lung cancer is the leading cause of death by cancer in North America. A decade ago, genomic rearrangements in the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase were identified in a subset of non-small cell lung carcinoma (NSCLC) patients. Soon after, crizotinib, a small molecule ATP-comp...

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Veröffentlicht in:Mol Cancer
Hauptverfasser: Golding, Brandon, Luu, Anita, Jones, Robert, Viloria-Petit, Alicia M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817728/
https://ncbi.nlm.nih.gov/pubmed/29455675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-018-0810-4
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