Enantioselective Synthesis of the Cyclopiazonic Acid Family Using Sulfur Ylides

A convergent, nine‐step (LLS), enantioselective synthesis of α‐cyclopiazonic acid and related natural products is reported. The route features a) an enantioselective aziridination of an imine with a chiral sulfur ylide; b) a bioinspired (3+2)‐cycloaddition of the aziridine onto an alkene; and c) ins...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Zhurakovskyi, Oleksandr, Türkmen, Yunus E., Löffler, Lorenz E., Moorthie, Vijayalakshmi A., Chen, C. Chun, Shaw, Michael A., Crimmin, Mark R., Ferrara, Marco, Ahmad, Mushtaq, Ostovar, Mehrnoosh, Matlock, Johnathan V., Aggarwal, Varinder K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817397/
https://ncbi.nlm.nih.gov/pubmed/29265694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201712065
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