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Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives

Farnesol, a sesquiterpene alcohol, potentiates the activity of β-lactam antibiotics against antibiotic-resistant bacteria. We document that farnesol and two synthetic derivatives (compounds 2 and 6) have poor antibacterial activities of their own, but they potentiate the activities of ampicillin and...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Kim, Choon, Hesek, Dusan, Lee, Mijoon, Mobashery, Shahriar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817034/
https://ncbi.nlm.nih.gov/pubmed/29402738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.01.028
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