Genome-Wide Association Study Reveals Greater Polygenic Loading for Schizophrenia in Cases With a Family History of Illness

Genome-wide association studies (GWAS) of schizophrenia have yielded more than 100 common susceptibility variants, and strongly support a substantial polygenic contribution of a large number of small allelic effects. It has been hypothesized that familial schizophrenia is largely a consequence of in...

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Udgivet i:Am J Med Genet B Neuropsychiatr Genet
Main Authors: Bigdeli, Tim B., Ripke, Stephan, Bacanu, Silviu-Alin, Lee, Sang Hong, Wray, Naomi R., Gejman, Pablo V., Rietschel, Marcella, Cichon, Sven, St Clair, David, Corvin, Aiden, Kirov, George, McQuillin, Andrew, Gurling, Hugh, Rujescu, Dan, Andreassen, Ole A., Werge, Thomas, Blackwood, Douglas H.R., Pato, Carlos N., Pato, Michele T., Malhotra, Anil K., O’Donovan, Michael C., Kendler, Kenneth S., Fanous, Ayman H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816590/
https://ncbi.nlm.nih.gov/pubmed/26663532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.b.32402
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