Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer

Dipeptidyl peptidases 8 and 9 are intracellular N-terminal dipeptidyl peptidases (preferentially postproline) associated with pathophysiological roles in immune response and cancer biology. While the DPP family member DPP4 is extensively characterized in molecular terms as a validated therapeutic ta...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Ross, Breyan, Krapp, Stephan, Augustin, Martin, Kierfersauer, Reiner, Arciniega, Marcelino, Geiss-Friedlander, Ruth, Huber, Robert
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816189/
https://ncbi.nlm.nih.gov/pubmed/29382749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717565115
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