Anti–PD-1/anti–CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8(+) T cell trafficking

Inhibition of immune checkpoints programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells results in durable antitumor activity in melanoma patients. Despite high frequency of melanoma brain metastases (BrM) and associated poor prognosis, the activity and mechani...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Taggart, David, Andreou, Tereza, Scott, Karen J., Williams, Jennifer, Rippaus, Nora, Brownlie, Rebecca J., Ilett, Elizabeth J., Salmond, Robert J., Melcher, Alan, Lorger, Mihaela
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816160/
https://ncbi.nlm.nih.gov/pubmed/29386395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714089115
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