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Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB
Biologics are a rapidly growing class of therapeutics with many advantages over traditional small molecule drugs. A major obstacle to their development is that proteins and peptides are easily destroyed by proteases and, thus, typically have prohibitively short half-lives in human gut, plasma, and c...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5816147/ https://ncbi.nlm.nih.gov/pubmed/29378946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711837115 |
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