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Insight into the reaction mechanism of lipoyl synthase: a QM/MM study
Lipoyl synthase (LipA) catalyses the final step of the biosynthesis of the lipoyl cofactor by insertion of two sulfur atoms at the C6 and C8 atoms of the protein-bound octanoyl substrate. In this reaction, two [4Fe4S] clusters and two molecules of S-adenosyl-l-methionine are used. One of the two FeS...
Shranjeno v:
| izdano v: | J Biol Inorg Chem |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Springer Berlin Heidelberg
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5816104/ https://ncbi.nlm.nih.gov/pubmed/29204715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-017-1522-8 |
| Oznake: |
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