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Insight into the reaction mechanism of lipoyl synthase: a QM/MM study

Lipoyl synthase (LipA) catalyses the final step of the biosynthesis of the lipoyl cofactor by insertion of two sulfur atoms at the C6 and C8 atoms of the protein-bound octanoyl substrate. In this reaction, two [4Fe4S] clusters and two molecules of S-adenosyl-l-methionine are used. One of the two FeS...

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Bibliografiske detaljer
Udgivet i:J Biol Inorg Chem
Main Authors: Dong, Geng, Cao, Lili, Ryde, Ulf
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816104/
https://ncbi.nlm.nih.gov/pubmed/29204715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-017-1522-8
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