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A Distinct Mechanism of Senescence Activation in Amnion Epithelial Cells by Infection, Inflammation and Oxidative Stress

PROBLEM: We investigated p38MAPK activation-induced fetal membrane cell senescence in response to inflammation (tumor necrosis factor-alpha [TNF-α]) and infection (lipopolysaccharide [LPS]), factors associated with spontaneous preterm birth. METHOD OF STUDY: Primary amnion epithelial cells (AECs) we...

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Detalhes bibliográficos
Publicado no:Am J Reprod Immunol
Main Authors: DIXON, C. Luke, RICHARDSON, Lauren, SHELLER-MILLER, Samantha, SAADE, George, MENON, Ramkumar
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815890/
https://ncbi.nlm.nih.gov/pubmed/29193446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/aji.12790
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