Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression

Genome-wide association studies (GWAS) have identified multiple common susceptibility loci for pancreatic cancer. Here we report fine-mapping and functional analysis of one such locus residing in a 610 kb gene desert on chr13q22.1 (marked by rs9543325). The closest candidate genes, KLF5, KLF12, PIBF...

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Publicado no:Hum Mol Genet
Main Authors: Hoskins, Jason W., Ibrahim, Abdisamad, Emmanuel, Mickey A., Manmiller, Sarah M., Wu, Yinglun, O’Neill, Maura, Jia, Jinping, Collins, Irene, Zhang, Mingfeng, Thomas, Janelle V., Rost, Lauren M., Das, Sudipto, Parikh, Hemang, Haake, Jefferson M., Matters, Gail L., Kurtz, Robert C., Bamlet, William R., Klein, Alison, Stolzenberg-Solomon, Rachael, Wolpin, Brian M., Yarden, Ronit, Wang, Zhaoming, Smith, Jill, Olson, Sara H., Andresson, Thorkell, Petersen, Gloria M., Amundadottir, Laufey T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815622/
https://ncbi.nlm.nih.gov/pubmed/28172817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw300
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