Muscarinic type-1 receptors regulate I(K,ACh) in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation

BACKGROUND: Basal and acetylcholine-gated inward-rectifier K(+)-currents (I(K1) and I(K,ACh), respectively) are altered in atrial fibrillation (AF). G(i)-protein-coupled muscarinic (M) receptors type-2 are considered the predominant receptors activating I(K,ACh). Although a role for G(q)-coupled non...

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Gepubliceerd in:Int J Cardiol
Hoofdauteurs: Heijman, Jordi, Knuschke, Dorit, Kunze, Franziska, Chrétien, Eva Maria, Michel-Reher, Martina B., Voigt, Niels, Knaut, Michael, Michel, Martin C., Ravens, Ursula, Dobrev, Dobromir
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815374/
https://ncbi.nlm.nih.gov/pubmed/29290419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2017.12.050
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