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Targeting the Programmed Death-1 Pathway in Lymphoid Neoplasms
Programmed death-1 (PD-1) is a co-inhibitory molecule and is seen in CD4+ and CD8+ T cells. Upon binding to its ligands, programmed death ligand-1 (PD-L1) and -2 (PD-L2), PD-1 negatively regulates interleukin 2 (IL-2) production and T cell proliferation. Activated effector T-cells, which kill cancer...
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| Publicado no: | Cancer Treat Rev |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5815314/ https://ncbi.nlm.nih.gov/pubmed/28242522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ctrv.2017.01.009 |
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