Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma

Mutations in DNA repair genes lead to increased genomic instability and mutation frequency. These mutations represent potential biomarkers for cancer immunotherapy efficacy, as high tumor mutational burden has been associated with increased neo-antigens and tumor infiltrating lymphocytes. While mism...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Chae, Young Kwang, Anker, Jonathan F., Bais, Preeti, Namburi, Sandeep, Giles, Francis J., Chuang, Jeffrey H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2017
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814272/
https://ncbi.nlm.nih.gov/pubmed/29487705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23742
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