MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children’s oncology group

Neuroblastomas with a high mitosis-karyorrhexis index (High-MKI) are often associated with MYCN amplification, MYCN protein overexpression and adverse clinical outcome. However, the prognostic effect of MYC-family protein expression on these neuroblastomas is less understood, especially when MYCN is...

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Pubblicato in:Oncotarget
Autori principali: Niemas-Teshiba, Risa, Matsuno, Ryosuke, Wang, Larry L., Tang, Xao X., Chiu, Bill, Zeki, Jasmine, Coburn, Jeannine, Ornell, Kimberly, Naranjo, Arlene, Van Ryn, Collin, London, Wendy B., Hogarty, Michael D., Gastier-Foster, Julie M., Look, A. Thomas, Park, Julie R., Maris, John M., Cohn, Susan L., Seeger, Robert C., Asgharzadeh, Shahab, Ikegaki, Naohiko, Shimada, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814222/
https://ncbi.nlm.nih.gov/pubmed/29464082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23740
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