Demonstration of Nucleoside Transporter Activity in the Nose-to-Brain Distribution of [(18)F]Fluorothymidine Using PET Imaging

PURPOSE: To evaluate the role of nucleoside transporters in the nose-to-brain uptake of [(18)F]fluorothymidine (FLT), an equilibrative nucleoside transporter (ENT1,2) and concentrative nucleoside transporter (CNT1–3) substrate, using PET to measure local tissue concentrations. METHODS: Anesthetized...

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Bibliografske podrobnosti
izdano v:AAPS J
Main Authors: Boles Ponto, Laura L., Huang, Jiangeng, Walsh, Susan A., Acevedo, Michael R., Mundt, Christine, Sunderland, John, Donovan, Maureen
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814119/
https://ncbi.nlm.nih.gov/pubmed/29218445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-017-0158-5
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