Multiplex CRISPR/Cas9 system impairs HCMV replication by excising an essential viral gene

Anti-HCMV treatments used in immunosuppressed patients reduce viral replication, but resistant viral strains can emerge. Moreover, these drugs do not target latently infected cells. We designed two anti-viral CRISPR/Cas9 strategies to target the UL122/123 gene, a key regulator of lytic replication a...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Gergen, Janina, Coulon, Flora, Creneguy, Alison, Elain-Duret, Nathan, Gutierrez, Alejandra, Pinkenburg, Olaf, Verhoeyen, Els, Anegon, Ignacio, Nguyen, Tuan Huy, Halary, Franck Albert, Haspot, Fabienne
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813945/
https://ncbi.nlm.nih.gov/pubmed/29447206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192602
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