Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin‐of‐exposure values for hexavalent chromium

The current US Environmental Protection Agency (EPA) reference dose (RfD) for oral exposure to chromium, 0.003 mg kg(−1) day(−1), is based on a no‐observable‐adverse‐effect‐level from a 1958 bioassay of rats exposed to ≤25 ppm hexavalent chromium [Cr(VI)] in drinking water. EPA characterizes the con...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Appl Toxicol
Main Authors: Thompson, Chad M., Kirman, Christopher R., Hays, Sean M., Suh, Mina, Harvey, Seneca E., Proctor, Deborah M., Rager, Julia E., Haws, Laurie C., Harris, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813206/
https://ncbi.nlm.nih.gov/pubmed/29064106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jat.3545
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados