Single‐dose euglycaemic clamp studies demonstrating pharmacokinetic and pharmacodynamic similarity between MK‐1293 insulin glargine and originator insulin glargine (Lantus) in subjects with type 1 diabetes and healthy subjects

AIMS: MK‐1293 is an insulin glargine that has an amino acid sequence identical to that of Lantus, the originator insulin glargine. Two euglycaemic clamp studies, 1 in subjects with type 1 diabetes (T1D) and 1 in healthy subjects, were conducted to demonstrate pharmacokinetic (PK) and pharmacodynamic...

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Vydáno v:Diabetes Obes Metab
Hlavní autoři: Crutchlow, Michael F., Palcza, John S., Mostoller, Kate M., Mahon, Chantal D., Barbour, April M., Marcos, Michael C., Xu, Yang, Watkins, Elaine, Morrow, Linda, Hompesch, Marcus
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2017
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813203/
https://ncbi.nlm.nih.gov/pubmed/28817223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.13084
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