Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a clear understanding of polycystin proteins’ functions as ion channels. This question remains unsolved largely because polycyst...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Liu, Xiaowen, Vien, Thuy, Duan, Jingjing, Sheu, Shu-Hsien, DeCaen, Paul G, Clapham, David E
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Structural Biology and Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812715/
https://ncbi.nlm.nih.gov/pubmed/29443690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33183
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