Phase I study of tomuzotuximab, a glycoengineered therapeutic antibody against the epidermal growth factor receptor, in patients with advanced carcinomas

BACKGROUND: Changes in glycosylation of the constant domain (Fc) of monoclonal antibodies (mAbs) enhance antibody-dependent cell-mediated cytotoxicity independently of downstream effects following receptor blockade by the antibody, thus extending their indication. We investigated the safety, pharmac...

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Bibliographic Details
Published in:ESMO Open
Main Authors: Fiedler, Walter, Cresta, Sara, Schulze-Bergkamen, Henning, De Dosso, Sara, Weidmann, Jens, Tessari, Anna, Baumeister, Hans, Danielczyk, Antje, Dietrich, Bruno, Goletz, Steffen, Zurlo, Alfredo, Salzberg, Marc, Sessa, Cristiana, Gianni, Luca
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2018
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812399/
https://ncbi.nlm.nih.gov/pubmed/29464112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/esmoopen-2017-000303
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