Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3Kδ inhibitors and VIP antagonists

Adoptive therapy with ex vivo–expanded genetically modified antigen-specific T cells can induce remissions in patients with relapsed/refractory cancer. The clinical success of this therapy depends upon efficient transduction and expansion of T cells ex vivo and their homing, persistence and cytotoxi...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Petersen, Christopher T., Hassan, Mojibade, Morris, Anna B., Jeffery, Jasmin, Lee, Kunhee, Jagirdar, Neera, Staton, Ashley D., Raikar, Sunil S., Spencer, Harold T., Sulchek, Todd, Flowers, Christopher R., Waller, Edmund K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812323/
https://ncbi.nlm.nih.gov/pubmed/29386194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017011254
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