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Highly enantioselective access to diketopiperazines via cinchona alkaloid catalyzed Michael additions

Michael addition reactions of triketopiperazine (TKP) derivatives to enones, mediated by a cinchona alkaloid-derived catalyst, deliver products in high yield and enantiomeric ratio (er). Use of unsaturated ester, nitrile or sulfone partners gives bridged hydroxy-diketopiperazine (DKP) products resul...

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Bibliografische gegevens
Gepubliceerd in:Chem Sci
Hoofdauteurs: Cabanillas, Alejandro, Davies, Christopher D., Male, Louise, Simpkins, Nigel S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Royal Society of Chemistry 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811140/
https://ncbi.nlm.nih.gov/pubmed/29560222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc03218g
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