Design, synthesis and preliminary antimicrobial evaluation of N-alkyl chain-tethered C-5 functionalized bis-isatins

A series of N-alkyl-tethered C-5 functionalized bis-isatins were synthesized and evaluated for their antimicrobial activity against pathogenic microorganisms. The preliminary evaluation studies revealed compound 4t, with an optimal combination of a bromo substituent at the C-5 position of the isatin...

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Veröffentlicht in:Medchemcomm
Hauptverfasser: Singh, Amandeep, Nisha, Bains, Trpta, Hahn, Hye Jee, Liu, Nicole, Tam, Christina, Cheng, Luisa W., Kim, Jong, Debnath, Anjan, Land, Kirkwood M., Kumar, Vipan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2017
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810968/
https://ncbi.nlm.nih.gov/pubmed/29449910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00434f
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