Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respiration

PURPOSE: Mutations in PTEN-induced putative kinase 1 (Pink1), a mitochondrial serine/threonine kinase, cause a recessive inherited form of Parkinson’s disease (PD). Pink1 deletion in rats results in a progressive PD-like phenotype, characterized by significant motor deficits starting at 4 months of...

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Xehetasun bibliografikoak
Argitaratua izan da:Proteomics Clin Appl
Egile Nagusiak: Stauch, Kelly L., Villeneuve, Lance M., Purnell, Phillip R., Ottemann, Brendan M., Emanuel, Katy, Fox, Howard S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810131/
https://ncbi.nlm.nih.gov/pubmed/27568932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prca.201600005
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