Mesenchymal stromal cells inhibit NLRP3 inflammasome activation in a model of Coxsackievirus B3-induced inflammatory cardiomyopathy

Inflammation in myocarditis induces cardiac injury and triggers disease progression to heart failure. NLRP3 inflammasome activation is a newly identified amplifying step in the pathogenesis of myocarditis. We previously have demonstrated that mesenchymal stromal cells (MSC) are cardioprotective in C...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Miteva, Kapka, Pappritz, Kathleen, Sosnowski, Marzena, El-Shafeey, Muhammad, Müller, Irene, Dong, Fengquan, Savvatis, Konstantinos, Ringe, Jochen, Tschöpe, Carsten, Van Linthout, Sophie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809634/
https://ncbi.nlm.nih.gov/pubmed/29434214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20686-6
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