Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells

Adrenal insufficiency is managed by hormone replacement therapy, which is far from optimal; the ability to generate functional steroidogenic cells would offer a unique opportunity for a curative approach to restoring the complex feedback regulation of the hypothalamic-pituitary-adrenal axis. Here, w...

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Publicado en:Cell Rep
Main Authors: Ruiz-Babot, Gerard, Balyura, Mariya, Hadjidemetriou, Irene, Ajodha, Sharon J., Taylor, David R., Ghataore, Lea, Taylor, Norman F., Schubert, Undine, Ziegler, Christian G., Storr, Helen L., Druce, Maralyn R., Gevers, Evelien F., Drake, William M., Srirangalingam, Umasuthan, Conway, Gerard S., King, Peter J., Metherell, Louise A., Bornstein, Stefan R., Guasti, Leonardo
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809617/
https://ncbi.nlm.nih.gov/pubmed/29386111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.003
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