LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer

Current understanding of aggressive human basal-like triple-negative breast cancer (TNBC) remains incomplete. In this study, we show endothelial lipase (LIPG) is aberrantly overexpressed in basal-like TNBCs. We demonstrate that LIPG is required for in vivo tumorigenicity and metastasis of TNBC cells...

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Udgivet i:eLife
Main Authors: Lo, Pang-Kuo, Yao, Yuan, Lee, Ji Shin, Zhang, Yongshu, Huang, Weiliang, Kane, Maureen A, Zhou, Qun
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809145/
https://ncbi.nlm.nih.gov/pubmed/29350614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31334
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