Inositol-Requiring Enzyme 1-Mediated Downregulation of MicroRNA (miR)-146a and miR-155 in Primary Dermal Fibroblasts across Three TNFRSF1A Mutations Results in Hyperresponsiveness to Lipopolysaccharide

Tumor necrosis factor (TNF)-receptor-associated periodic fever syndrome (TRAPS) is a rare monogenic autoinflammatory disorder characterized by mutations in the TNFRSF1A gene, causing TNF-receptor 1 (TNFR1) misfolding, increased cellular stress, activation of the unfolded protein response (UPR), and...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Harrison, Stephanie R., Scambler, Thomas, Oubussad, Lylia, Wong, Chi, Wittmann, Miriam, McDermott, Michael F., Savic, Sinisa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808292/
https://ncbi.nlm.nih.gov/pubmed/29467762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00173
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