Sublingual Administration of Sildenafil Oro-dispersible Film: New Profiles of Drug Tolerability and Pharmacokinetics for PDE5 Inhibitors

Objective: Type 5 phosphodiesterase inhibitors (PDE5i) are efficient drugs used for treatment of erectile dysfunction (ED); however, a large discontinuation rate due to major side effects is reported. The aim of this study was to evaluate the possible improvement of sildenafil (Sild) pharmacokinetic...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: De Toni, Luca, De Rocco Ponce, Maurizio, Franceschinis, Erica, Dall’Acqua, Stefano, Padrini, Roberto, Realdon, Nicola, Garolla, Andrea, Foresta, Carlo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808105/
https://ncbi.nlm.nih.gov/pubmed/29467656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00059
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