Darunavir/cobicistat showing similar effectiveness as darunavir/ritonavir monotherapy despite lower trough concentrations

INTRODUCTION: When darunavir (DRV) 800 mg is boosted with 150 mg cobicistat (DRV (cobi)), DRV trough concentration (C(trough)) is about 30% lower as compared to 100 mg ritonavir (DRV (rtv)). DRV (cobi) shows similar virological efficacy as DRV (rtv) when combined with two nucleos(t)ide analogue reve...

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Detalhes bibliográficos
Publicado no:J Int AIDS Soc
Main Authors: Gutierrez‐Valencia, Alicia, Trujillo‐Rodriguez, Maria, Fernandez‐Magdaleno, Tamara, Espinosa, Nuria, Viciana, Pompeyo, López‐Cortés, Luis F
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808101/
https://ncbi.nlm.nih.gov/pubmed/29430854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jia2.25072
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