2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy

Numerous experimental studies have supported the evidence that 2-methoxyestradiol (2 ME) is a biologically active metabolite that mediates multiple effects on the cardiovascular system, largely independent of the estrogen receptor. 2 ME is a major cytochrome P450 1B1 (CYP1B1) metabolite and has been...

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Udgivet i:Sci Rep
Main Authors: Maayah, Zaid H., Levasseur, Jody, Siva Piragasam, Ramanaguru, Abdelhamid, Ghada, Dyck, Jason R. B., Fahlman, Richard P., Siraki, Arno G., El-Kadi, Ayman O. S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807528/
https://ncbi.nlm.nih.gov/pubmed/29426916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20613-9
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