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Differential gene expression induced by anti-cancer agent plumbagin is mediated by androgen receptor in prostate cancer cells
Treatment of mice harboring PTEN-P2 tumors in the prostate or on prostate tissue in vivo with 5-hydroxy-2-methyl-1,4-naphthoquinone, also known as plumbagin, results in tumor regression in castrated mice, but not in intact mice. This suggested that dihydrotestosterone (DHT) production in the testes...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807367/ https://ncbi.nlm.nih.gov/pubmed/29426892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20451-9 |
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