IL-11 is a crucial determinant of cardiovascular fibrosis

Fibrosis is a common pathology in cardiovascular disease(1). In the heart, fibrosis causes mechanical and electrical dysfunction(1,2) and in the kidney, it predicts the onset of renal failure(3). Transforming growth factor β1 (TGFβ1) is the principal pro-fibrotic factor(4,5), but its inhibition is a...

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izdano v:Nature
Main Authors: Schafer, Sebastian, Viswanathan, Sivakumar, Widjaja, Anissa A., Lim, Wei-Wen, Moreno-Moral, Aida, DeLaughter, Daniel M., Ng, Benjamin, Patone, Giannino, Chow, Kingsley, Khin, Ester, Tan, Jessie, Chothani, Sonia P., Ye, Lei, Rackham, Owen J. L., Ko, Nicole S. J., Sahib, Norliza E., Pua, Chee Jian, Zhen, Nicole T. G., Xie, Chen, Wang, Mao, Maatz, Henrike, Lim, Shiqi, Saar, Kathrin, Blachut, Susanne, Petretto, Enrico, Schmidt, Sabine, Putoczki, Tracy, Guimarães-Camboa, Nuno, Wakimoto, Hiroko, van Heesch, Sebastiaan, Sigmundsson, Kristmundur, Lim, See L., Soon, Jia L., Chao, Victor T. T., Chua, Yeow L., Tan, Teing E., Evans, Sylvia M., Loh, Yee J., Jamal, Muhammad H., Ong, Kim K., Chua, Kim C., Ong, Boon-Hean, Chakaramakkil, Mathew J., Seidman, Jonathan G., Seidman, Christine E., Hubner, Norbert, Sin, Kenny Y. K., Cook, Stuart A.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807082/
https://ncbi.nlm.nih.gov/pubmed/29160304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24676
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