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Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand
Dysregulated mitophagy has been linked to Parkinson's disease (PD) due to the role of PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced mitophagy in vitro. Elegant mouse reporters have revealed the pervasive nature of basal mitophagy in vivo, yet the role of PINK1 and tissue met...
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| Publicado no: | Cell Metab |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807059/ https://ncbi.nlm.nih.gov/pubmed/29337137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.12.008 |
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