Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

Dysregulated mitophagy has been linked to Parkinson's disease (PD) due to the role of PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced mitophagy in vitro. Elegant mouse reporters have revealed the pervasive nature of basal mitophagy in vivo, yet the role of PINK1 and tissue met...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Metab
Hlavní autoři: McWilliams, Thomas G., Prescott, Alan R., Montava-Garriga, Lambert, Ball, Graeme, Singh, François, Barini, Erica, Muqit, Miratul M.K., Brooks, Simon P., Ganley, Ian G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807059/
https://ncbi.nlm.nih.gov/pubmed/29337137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.12.008
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky