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Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces. Since in vivo validation is not possible for the h...

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Podrobná bibliografie
Vydáno v:eLife
Hlavní autoři: Morgani, Sophie M, Metzger, Jakob J, Nichols, Jennifer, Siggia, Eric D, Hadjantonakis, Anna-Katerina
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807051/
https://ncbi.nlm.nih.gov/pubmed/29412136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32839
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