Palmitic Acid Hydroxy Stearic Acids Activate GPR40 Which is Involved in Their Beneficial Effects on Glucose Homeostasis

PAHSAs are endogenous lipids with anti-diabetic and anti-inflammatory effects. PAHSA levels are reduced in serum and adipose tissue of insulin-resistant people and high-fat-diet (HFD)-fed mice. Here, we investigated whether chronic PAHSA treatment enhances insulin sensitivity and which receptors med...

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Bibliografske podrobnosti
izdano v:Cell Metab
Main Authors: Syed, Ismail, Lee, Jennifer, Moraes-Vieira, Pedro M., Donaldson, Cynthia J., Sontheimer, Alexandra, Aryal, Pratik, Wellenstein, Kerry, Kolar, Matthew J, Nelson, Andrew T, Siegel, Dionicio, Mokrosinski, Jacek, Farooqi, I. Sadaf, Zhao, Juan Juan, Yore, Mark M., Peroni, Odile D., Saghatelian, Alan, Kahn, Barbara B.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807007/
https://ncbi.nlm.nih.gov/pubmed/29414687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.01.001
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