Cardioprotection and lifespan extension by the natural polyamine spermidine

Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spe...

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Publicado no:Nat Med
Main Authors: Eisenberg, Tobias, Abdellatif, Mahmoud, Schroeder, Sabrina, Primessnig, Uwe, Stekovic, Slaven, Pendl, Tobias, Harger, Alexandra, Schipke, Julia, Zimmermann, Andreas, Schmidt, Albrecht, Tong, Mingming, Ruckenstuhl, Christoph, Dammbrueck, Christopher, Gross, Angelina S., Herbst, Viktoria, Magnes, Christoph, Trausinger, Gert, Narath, Sophie, Meinitzer, Andreas, Hu, Zehan, Kirsch, Alexander, Eller, Kathrin, Gutierrez, Didac-Carmona, Büttner, Sabrina, Pietrocola, Federico, Knittelfelder, Oskar, Schrepfer, Emilie, Rockenfeller, Patrick, Simonini, Corinna, Rahn, Alexandros, Horsch, Marion, Moreth, Kristin, Beckers, Johannes, Fuchs, Helmut, Gailus-Durner, Valerie, Neff, Frauke, Janik, Dirk, Rathkolb, Birgit, Rozman, Jan, de Angelis, Martin Hrabe, Moustafa, Tarek, Haemmerle, Guenter, Mayr, Manuel, Willeit, Peter, von Frieling-Salewsky, Marion, Pieske, Burkert, Scorrano, Luca, Pieber, Thomas, Pechlaner, Raimund, Willeit, Johann, Sigrist, Stephan J., Linke, Wolfgang A., Mühlfeld, Christian, Sadoshima, Junichi, Dengjel, Joern, Kiechl, Stefan, Kroemer, Guido, Sedej, Simon, Madeo, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806691/
https://ncbi.nlm.nih.gov/pubmed/27841876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4222
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