Cardioprotection and lifespan extension by the natural polyamine spermidine

Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Med
Prif Awduron: Eisenberg, Tobias, Abdellatif, Mahmoud, Schroeder, Sabrina, Primessnig, Uwe, Stekovic, Slaven, Pendl, Tobias, Harger, Alexandra, Schipke, Julia, Zimmermann, Andreas, Schmidt, Albrecht, Tong, Mingming, Ruckenstuhl, Christoph, Dammbrueck, Christopher, Gross, Angelina S., Herbst, Viktoria, Magnes, Christoph, Trausinger, Gert, Narath, Sophie, Meinitzer, Andreas, Hu, Zehan, Kirsch, Alexander, Eller, Kathrin, Gutierrez, Didac-Carmona, Büttner, Sabrina, Pietrocola, Federico, Knittelfelder, Oskar, Schrepfer, Emilie, Rockenfeller, Patrick, Simonini, Corinna, Rahn, Alexandros, Horsch, Marion, Moreth, Kristin, Beckers, Johannes, Fuchs, Helmut, Gailus-Durner, Valerie, Neff, Frauke, Janik, Dirk, Rathkolb, Birgit, Rozman, Jan, de Angelis, Martin Hrabe, Moustafa, Tarek, Haemmerle, Guenter, Mayr, Manuel, Willeit, Peter, von Frieling-Salewsky, Marion, Pieske, Burkert, Scorrano, Luca, Pieber, Thomas, Pechlaner, Raimund, Willeit, Johann, Sigrist, Stephan J., Linke, Wolfgang A., Mühlfeld, Christian, Sadoshima, Junichi, Dengjel, Joern, Kiechl, Stefan, Kroemer, Guido, Sedej, Simon, Madeo, Frank
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806691/
https://ncbi.nlm.nih.gov/pubmed/27841876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4222
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