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Value of information methods to design a clinical trial in a small population to optimise a health economic utility function

BACKGROUND: Most confirmatory randomised controlled clinical trials (RCTs) are designed with specified power, usually 80% or 90%, for a hypothesis test conducted at a given significance level, usually 2.5% for a one-sided test. Approval of the experimental treatment by regulatory agencies is then ba...

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Pubblicato in:BMC Med Res Methodol
Autori principali: Pearce, Michael, Hee, Siew Wan, Madan, Jason, Posch, Martin, Day, Simon, Miller, Frank, Zohar, Sarah, Stallard, Nigel
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806391/
https://ncbi.nlm.nih.gov/pubmed/29422021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-018-0475-0
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