Acidic organelles mediate TGF-β1-induced cellular fibrosis via (pro)renin receptor and vacuolar ATPase trafficking in human peritoneal mesothelial cells

TGF-β1, which can cause renal tubular injury through a vacuolar-type H(+)-ATPase (V-ATPase)-mediated pathway, is induced by the glucose degradation product methylglyoxal to yield peritoneal injury and fibrosis. The present study investigated the roles of V-ATPase and its accessory protein, the (pro)...

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Publicado en:Sci Rep
Main Authors: Oba-Yabana, Ikuko, Mori, Takefumi, Takahashi, Chika, Hirose, Takuo, Ohsaki, Yusuke, Kinugasa, Satoshi, Muroya, Yoshikazu, Sato, Emiko, Nguyen, Geneviève, Piedagnel, Rémi, Ronco, Pierre M., Totsune, Kazuhito, Ito, Sadayoshi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805675/
https://ncbi.nlm.nih.gov/pubmed/29422602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20940-x
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