Multi-trait analysis of genome-wide association summary statistics using MTAG

We introduce Multi-Trait Analysis of GWAS (MTAG), a method for joint analysis of summary statistics from GWASs of different traits, possibly from overlapping samples. We apply MTAG to summary statistics for depressive symptoms (N(eff) = 354,862), neuroticism (N = 168,105), and subjective well-being...

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Udgivet i:Nat Genet
Main Authors: Turley, Patrick, Walters, Raymond K., Maghzian, Omeed, Okbay, Aysu, Lee, James J., Fontana, Mark Alan, Nguyen-Viet, Tuan Anh, Wedow, Robbee, Zacher, Meghan, Furlotte, Nicholas A., Magnusson, Patrik, Oskarsson, Sven, Johannesson, Magnus, Visscher, Peter M., Laibson, David, Cesarini, David, Neale, Benjamin M., Benjamin, Daniel J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805593/
https://ncbi.nlm.nih.gov/pubmed/29292387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-017-0009-4
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