Aptamer–drug conjugate: targeted delivery of doxorubicin in a HER3 aptamer-functionalized liposomal delivery system reduces cardiotoxicity

INTRODUCTION: The toxic side effects of doxorubicin (DOX) have limited its use in chemotherapy. Neither liposomal DOX nor pegylated liposomal DOX are able to completely resolve this issue. This is a proof-of-concept study testing aptamer-drug conjugate (ApDC) targeted delivery systems for chemothera...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Dou, Xiao-qian, Wang, Hua, Zhang, Jing, Wang, Fang, Xu, Gui-li, Xu, Cheng-cheng, Xu, Huan-hua, Xiang, Shen-si, Fu, Jie, Song, Hai-feng
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5804143/
https://ncbi.nlm.nih.gov/pubmed/29440899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S149887
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