Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway

BACKGROUND: Prohibitin 1 (PHB) is a potential target for the treatment of urothelial carcinoma of the bladder (UCB). FL3 is a newly synthesized agent that inhibits cancer cell proliferation by targeting the PHB protein; however, the effect of FL3 in UCB cells remains unexplored. METHODS: FL3 was ide...

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Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Yuan, Gangjun, Chen, Xin, Liu, Zhuowei, Wei, Wensu, Shu, Qinghai, Abou-Hamdan, Hussein, Jiang, Lijuan, Li, Xiangdong, Chen, Rixin, Désaubry, Laurent, Zhou, Fangjian, Xie, Dan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5804081/
https://ncbi.nlm.nih.gov/pubmed/29415747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0695-5
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