Cathepsin K activity controls cardiotoxin‐induced skeletal muscle repair in mice

BACKGROUND: Cathepsin K (CatK) is a widely expressed cysteine protease that has gained attention because of its enzymatic and non‐enzymatic functions in signalling. Here, we examined whether CatK‐deficiency (CatK(−/−)) would mitigate injury‐related skeletal muscle remodelling and fibrosis in mice, w...

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Pubblicato in:J Cachexia Sarcopenia Muscle
Autori principali: Ogasawara, Shinyu, Cheng, Xian Wu, Inoue, Aiko, Hu, Lina, Piao, Limei, Yu, Chenglin, Goto, Hiroki, Xu, Wenhu, Zhao, Guangxian, Lei, Yanna, Yang, Guang, Kimura, Kaoru, Umegaki, Hiroyuki, Shi, Guo‐Ping, Kuzuya, Masafumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803616/
https://ncbi.nlm.nih.gov/pubmed/29058826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12248
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