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Trichloroethylene perturbs HNF4a expression and activity in the developing chick heart

Exposure to trichloroethylene (TCE) is linked to formation of congenital heart defects in humans and animals. Prior interactome analysis identified the transcription factor, Hepatocyte Nuclear Factor 4 alpha (HNF4a), as a potential target of TCE exposure. As a role for HNF4a is unknown in the heart,...

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Publicat a:Toxicol Lett
Autors principals: Harris, Alondra P., Ismail, Kareem A., Nunez, Martha, Martopullo, Ira, Lencinas, Alejandro, Selmin, Ornella I., Runyan, Raymond B.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803365/
https://ncbi.nlm.nih.gov/pubmed/29306027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2017.12.027
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