SJP-L-5 inhibits HIV-1 polypurine tract primed plus-strand DNA elongation, indicating viral DNA synthesis initiation at multiple sites under drug pressure

In a previous study the small molecule SJP-L-5 that inhibits HIV replication, has been shown to block uncoating of the viral capsid. Continued study showed that SJP-L-5 might hinder HIV capsid uncoating by blocking the completion of reverse transcription. However, to date, the mechanism has not been...

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מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Zhang, Xing-Jie, Wang, Rui-Rui, Chen, Huan, Luo, Rong-Hua, Yang, Liu-Meng, Liu, Jing-Ping, Sun, Han-Dong, Zhang, Hong-Bin, Xiao, Wei-Lie, Zheng, Yong-Tang
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2018
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803243/
https://ncbi.nlm.nih.gov/pubmed/29416083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20954-5
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