Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner

Reversible post-translational modifications represent a mechanism to control tumor metabolism. Here we show that mitochondrial Sirtuin5 (SIRT5), which mediates lysine desuccinylation, deglutarylation, and demalonylation, plays a role in colorectal cancer (CRC) glutamine metabolic rewiring. Metabolic...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Yun-Qian, Wang, Hao-Lian, Xu, Jie, Tan, Juan, Fu, Lin-Na, Wang, Ji-Lin, Zou, Tian-Hui, Sun, Dan-Feng, Gao, Qin-Yan, Chen, Ying-Xuan, Fang, Jing-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803207/
https://ncbi.nlm.nih.gov/pubmed/29416026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02951-4
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