DNA methylome profiling at single-base resolution through bisulfite sequencing of 5mC-immunoprecipitated DNA

BACKGROUND: Detection of DNA methylome at single-base resolution is a significant challenge but promises to shed considerable light on human disease etiology. Current technologies could not detect DNA methylation genome-wide at single-base resolution with small amount of sequencing data and could no...

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Veröffentlicht in:BMC Biotechnol
Hauptverfasser: Jia, Zhen, Shi, Yueyi, Zhang, Lei, Ren, Yipeng, Wang, Tong, Xing, Lejun, Zhang, Baorong, Gao, Guolan, Bu, Rongfa
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Methodology Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801686/
https://ncbi.nlm.nih.gov/pubmed/29409498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-017-0409-7
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