Fibrosis and Hypoxia-Inducible Factor-1α–Dependent Tumors of the Soft Tissue on Loss of Von Hippel-Lindau in Mesenchymal Progenitors

The hypoxia-inducible factor (Hif)-1α (Hif-1α) and Hif-2α (Epas1) have a critical role in both normal development and cancer. von Hippel Lindau (Vhl) protein, encoded by a tumor suppressor gene, is an E3 ubiquitin ligase that targets Hif-1α and Epas1 to the proteasome for degradation. To better unde...

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Pubblicato in:Am J Pathol
Autori principali: Mangiavini, Laura, Merceron, Christophe, Araldi, Elisa, Khatri, Richa, Gerard-O'Riley, Rita, Wilson, Tremika L., Sandusky, George, Abadie, Jerome, Lyons, Karen M., Giaccia, Amato J., Schipani, Ernestina
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801489/
https://ncbi.nlm.nih.gov/pubmed/26348575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.07.008
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