Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

The intestinal mucosal barrier is critical for host defense against pathogens infection. Here, we demonstrate that the mixed lineage kinase-like protein (MLKL), a necroptosis effector, promotes intestinal epithelial barrier function by enhancing inflammasome activation. MLKL(−/−) mice were more susc...

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書目詳細資料
發表在:Front Immunol
Main Authors: Yu, Shui-Xing, Chen, Wei, Liu, Zhen-Zhen, Zhou, Feng-Hua, Yan, Shi-Qing, Hu, Gui-Qiu, Qin, Xiao-Xia, Zhang, Jie, Ma, Ke, Du, Chong-Tao, Gu, Jing-Min, Deng, Xu-Ming, Han, Wen-Yu, Yang, Yong-Jun
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2018
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801401/
https://ncbi.nlm.nih.gov/pubmed/29456533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00119
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