Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

The intestinal mucosal barrier is critical for host defense against pathogens infection. Here, we demonstrate that the mixed lineage kinase-like protein (MLKL), a necroptosis effector, promotes intestinal epithelial barrier function by enhancing inflammasome activation. MLKL(−/−) mice were more susc...

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Библиографические подробности
Опубликовано в: :Front Immunol
Главные авторы: Yu, Shui-Xing, Chen, Wei, Liu, Zhen-Zhen, Zhou, Feng-Hua, Yan, Shi-Qing, Hu, Gui-Qiu, Qin, Xiao-Xia, Zhang, Jie, Ma, Ke, Du, Chong-Tao, Gu, Jing-Min, Deng, Xu-Ming, Han, Wen-Yu, Yang, Yong-Jun
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801401/
https://ncbi.nlm.nih.gov/pubmed/29456533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00119
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